Should the climatology be inserted in the center of the simulation domain?

For nested project, the climatologies do not need to be in the center.
For non-nested project, we would like some distance from the climatology to the border, because the boundary conditions at the border is artificial wind, so we need some distance to let the wind blowing to become more realistic.
However in the nested project, the boundary conditions at the border is from the coarse flow model. The wind is not artificial, but more realistic, so it requires less distance.